Regenerative Orthopedics Growing in Popularity

Bone Marrow Concentrate and Platelet Rich Plasma Are Growing in Popularity

Regenerative Orthopedics, such as Bone Marrow Concentrate (BMC) and Platelet Rich Plasma (PRP), are growing in popularity in sports medicine and other fields of medicine. That’s because PRP has been shown to boost healing in many types of injuries, and BMC is said to repair tissue like cartilage and bone.

A Short Explanation of PRP and BMC?

PRP is a concentration of platelets from a person’s own blood. The treatment uses the patient’s blood cells to accelerate healing in a specific area. Platelets contain growth factors that enhance the healing of soft tissue. When these platelets are concentrated, their healing potential increases.

BMC is an aspiration of mesenchymal stem cells from bone marrow, commonly taken from the iliac crest, and then concentrated. These stem cells can differentiate into cartilage and bone. BMC has the potential to heal injured and arthritic joints.

Platelet Rich Plasma provides a healing environment or “scaffold” to build on, enhances stem cell proliferation, and basically tells the stem cells what to do. In a 2012 study, doctors at the Shanghai Jiaotong University School of Medicine say that “PRP is a candidate bioactive scaffold capable of releasing endogenous growth factors and that bone marrow stem cells and adipose-derived stem cells seeded within the PRP scaffold were able to change into chondrocytes (cartilage building blocks) suitable for cell-based cartilage repair.”(1)

But does the research show that these treatments effectively repair joint injuries or even arthritis?

There is substantial research demonstrating the effectiveness of both PRP and BMC in repairing joint injuries and arthritis. The following are just some of the medical journal research results:

The Journal of Pain Research looked at 115 patients treated with BMC for arthritis and/or rotator cuff tears. What were the results? Both disability and pain decreased, and the improvement continued for up to 2 years. (2)

Another study comparing BMC’s effectiveness for rotator cuff tears with exercise also resulted in improved function, decreased pain, and tendon healing. The findings suggested that BMC may be a safe and effective alternative to conservative treatments such as exercise for managing rotator cuff tears. (3)

A study by Gobbi and associates on BMC for chondral defects of the knee showed significant improvement. (4) In another study, Gobbi also showed improvement in patellofemoral lesions of the knee with BMC. (5)

Can BMC help with arthritis? Several human studies suggest a potential role of BMC in treating knee osteoarthritis, evidenced by significant improvements in multiple clinical scores and increased cartilage healing. (6)

Stem Cells and PRP Are More Effective Than Hyaluronic Acid Treatments for Osteoarthritis

In the medical journal, Arthroscopy: The Journal of Arthroscopic & Related Surgery, researchers concluded, “Patients undergoing treatment for knee osteoarthritis with PRP or BMC can be expected to experience improved clinical outcomes when compared with patients who receive hyaluronic acid.” (7)

BMC and PRP Are Growing in Popularity, and They Are Effective Treatments

As you can see, PRP and BMC are effective for treating various joint injuries and arthritis. These Regenerative Orthopedic procedures are great non-surgical alternatives for those with persistent joint pain, joint injury, and even arthritis.

At OrthoRegen, we have years of experience treating patients with PRP and BMC. If you are looking for a non-surgical option for your joint pain or arthritis, please call us at 310-453-1234.

References

1. Xie X, Wang Y, Zhao C, Guo S, Liu S, Jia W, Tuan RS, Zhang C. Comparative evaluation of MSCs from bone marrow and adipose tissue seeded in PRP-derived scaffold for cartilage regeneration Biomaterials. 2012 Oct;33(29):7008-18. doi: 10.1016/j.biomaterials.2012.06.058. Epub 2012 Jul 19.
2. Centeno, Christopher J., et al. “A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis.” Journal of Pain Research 8 (2015): 269.
3. Centeno, Christopher, et al. “A randomized controlled trial of the treatment of rotator cuff tears with bone marrow concentrate and platelet products compared to exercise therapy: A midterm analysis.” Stem cells international 2020 (2020).
4. Gobbi A, Karnatzikos G, Sankineani SR. One-step surgery with multipotent stem cells for the treatment of large full- thickness chondral defects of the knee. Am J Sports Med. 2014;42:648–657.
5. Gobbi A, Chaurasia S, Karnatzikos G, et al. Matrix-induced autologous chondrocyte implantation versus multipotent stem cells for the treatment of large patellofemoral chondral lesions: a nonrandomized prospective trial. Cartilage. 2014;6:82–97.
6. Wolfstadt JI, Cole BJ, Ogilvie-Harris DJ, et al. Current concepts: the role of mesenchymal stem cells in the management of knee osteoarthritis. Sports Health. 2015;7:38–44.
7. Belk, John W., et al. “Patients With Knee Osteoarthritis Who Receive Platelet-Rich Plasma or Bone-Marrow Aspirate Concentrate Injections Have Better Outcomes Than Patients Who Receive Hyaluronic Acid: Systematic Review and Meta-analysis.” Arthroscopy: The Journal of Arthroscopic & Related Surgery (2023).